Caffeine and acetaminophen are a risky combination, capable of causing liver damage. New research has shown that consuming caffeine at the same time or close to taking acetaminophen (Tylenol, Panadol) greatly increases the risk of liver damage, particularly in people with hepatitis. It has long been known that combining alcohol with acetaminophen can cause liver harm, or even death. More recently it has been discovered that caffeine is also a problem. Acetaminophen (known as paracetamol in the UK and Australia) is one of the most popular over the counter medications for pain and fever.  However, despite its common usage, acetaminophen does have the potential to cause great harm to your liver.  It is capable of causing acute liver failure and even death (usually due to overdose); acetaminophen poisoning is responsible for more than 65,000 emergency room visits in the USA each year. The average healthy person is only at risk of harm caused by acetaminophen if they take more than the recommended dose.  However, people with hepatitis or a fatty liver are far more susceptible to liver damage. Therefore it is very important to avoid drinking coffee, energy drinks, caffeine-containing diet pills or large amounts of strong tea several hours before or after taking acetaminophen if you have a liver condition. It is also critical to be aware of the fact that some forms of Tylenol and Panadol actually combine acetaminophen with caffeine on purpose in the same tablet. This is because caffeine can speed the absorption of the medication, therefore may help to relieve pain more quickly. These types of products are generally marketed as fast acting or extra potent. If you value the health of your liver please avoid these products. You may unintentionally cause yourself irreversible liver damage. Reference