When we think about the health of our liver, we don’t associate this directly with the health of our brain.

A new clinical study has found that liver fibrosis (scarring in the liver) greatly increases the risk of brain shrinkage which leads to loss of mental function.

Healthy liver fibrosis liver

Fibrosis of the liver is caused by chronic inflammation in the liver and the problem is that this insidious condition is often missed and diagnosed too late. This can be prevented by having regular blood tests for liver function which will show the inflammation in the liver. This liver inflammation causes raised levels of liver enzymes in the blood. Other inflammatory markers to check are raised blood levels of C Reactive Protein (CRP) and ferritin.

The large study analysed behaviour in 447,626 participants 37 years and older over 9 years. Liver fibrosis showed significant associations with poor cognitive performance in reasoning, working memory, visual memory, executive function, and processing speed.

Neuroimaging analyses revealed significant associations between liver fibrosis and reduced regional grey matter volume (GMV) in the brain.

Brain white and gray matter

Grey matter is the most sophisticated part of the brain and has a higher concentration of brain cells. The GMV had shrunk in the brain regions known as the hippocampus, thalamus, ventral striatum, brain stem, and cerebellum.

CRP levels were significantly higher in adults with advanced liver fibrosis than those without, indicating an elevated systemic inflammation.

This study provides good evidence of associations between liver fibrosis, cognitive impairment, and loss of brain grey matter volume.

Liver inflammation is known as hepatitis and for more information see our videos on hepatitis.

Dementia is an epidemic in the aging population and liver inflammation is one of the reasons it is increasing. Liver inflammation can usually be reversed effectively with diet and lifestyle changes. Fatty liver is the most common cause of liver inflammation ad fibrosis and is associated with a diet high in carbohydrates, processed vegetable oils and sugar. Toxic environmental chemicals and microplastics can also cause liver inflammation.

Supplements to reduce liver inflammation include:

Livatone Plus which contains the clinically proven dose of the herb Milk Thistle combined with activated B vitamins, selenium, taurine and potent antioxidants. Livatone Plus is designed to improve liver function and help the liver to eliminate toxic chemicals from your body.

N-Acetyl-Cysteine (NAC) which increases the production of glutathione in the liver. Glutathione reduces liver inflammation and fibrosis. NAC is best taken in a dose of one to two capsules twice daily in between meals with a whole large glass of water.

Many people find that their mental clarity and sharpness improves greatly when they improve their liver health.

Early detection and prevention of liver diseases should reduce cognitive decline and loss of brain grey matter volume.

Reference

Rongtao Jiang et al, Elevated C-reactive protein mediates the liver-brain axis: a preliminary study

2023 Jun 23;93:104679.

doi: 10.1016/j.ebiom.2023.104679.

The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.