Berberine
Berberine is a herbal extract with a number of research-proven benefits to metabolism. It is especially beneficial for type 2 diabetics. Studies have shown berberine can help lower blood sugar and cholesterol, and it even makes weight loss easier.
Berberine is a natural plant extract, found in several different herbs. Examples include Goldenseal, barberry, oregon grape and phellodendron. It has a long tradition of use in Chinese Herbal Medicine. It is naturally yellow in color with an intensely bitter taste. Fortunately when taken in capsule form you can obtain all the benefits without having to experience the unpleasant taste.
An increasing amount of research is showing that berberine's blood sugar lowering and cholesterol lowering properties rival those of prescription drugs. In some instances berberine is at least as effective as some prescription drugs, but without harmful side effects. Berberine may make it easier for type 2 diabetics to control their blood sugar and their weight.
Effects of berberine on metabolism
Once berberine is absorbed into your bloodstream, one of its main actions is to activate an enzyme inside cells called AMP-activated protein kinase. This is a powerful enzyme with a number of important functions in your body.
These include:
- Stimulating oxidation (breakdown) of fatty acids inside the liver
- Stimulating the production of ketones (breakdown products of fat), to be used for energy
- Inhibiting the production of cholesterol and triglycerides
- Inhibiting lipogenesis (the creation of fat)
- Increasing the utilization of glucose by skeletal muscle cells (thereby helping to reduce elevated blood sugar)
- Regulating the production of insulin by beta cells in the pancreas, thus helping blood sugar control
These actions explain the enormous benefits berberine has for individuals with insulin resistance (syndrome X) and obesity.
Blood sugar control
Studies have shown that berberine can help to reduce elevated blood sugar in type 2 diabetics and is at least as effective as the prescription drug metformin (Glucophage, Diaformin). In one study, 116 patients with type 2 diabetes and elevated blood fats were given either one gram of berberine each day, or a placebo for three months. The group taking berberine experienced a 20 percent drop in their fasting blood sugar. It went from an average of 7.0 to 5.6 mmol/L (126 to 101 mg/dL). This means their blood sugar went from being diabetic to being in the normal range! The individuals taking berberine also experienced reductions in their cholesterol and triglycerides.
Berberine helps type 2 diabetics in a number of ways:
- It improves insulin sensitivity. If the cells of your body are more sensitive to insulin, your pancreas won't have to produce as much and you should experience better blood sugar control. It also helps to lower elevated blood insulin levels, which is good for people trying to lose weight and for women with polycystic ovarian syndrome.
- It reduces the amount of glucose that is produced inside your liver.
- Berberine reduces intestinal permeability (leaky gut) and improves the composition of the gut microbiome (the bacteria and other organisms living in the intestines).
A large review of 14 different studies (called a meta-analysis) has shown that berberine is as effective as the most commonly prescribed drugs for type 2 diabetes: metformin, rosiglitazone and glipizide.
Improvement in blood fats
Berberine can help to lower cholesterol and triglycerides if they are abnormally elevated. It does this by lowering an enzyme called PCSK9. This way, LDL cholesterol (which has traditionally been referred to as "bad cholesterol") can be removed from your bloodstream. This means cholesterol is less likely to accumulate on your artery walls and narrow them. Drugs that lower cholesterol by inhibiting the enzyme PCSK9 have only just received approval by the FDA. Some researchers believe they will be the next big thing after statins. Many people are forced to discontinue taking statins because of terrible side effects such as muscle pain, inflammation in the liver and impaired cognitive function. There is a lot of information about cholesterol in the book Cholesterol the Real Truth.
Studies have shown that berberine can also lower apolipoprotein B by between 13 and 15 percent. This is important because several studies have shown that elevated apolipoprotein B is a bigger risk factor for cardiovascular disease than elevated LDL cholesterol. It is said to be more atherogenic.
Making it easier to lose weight
Some of the most exciting studies done on berberine are those involving weight loss. People with type 2 diabetes, elevated cholesterol, high blood pressure or polycystic ovarian syndrome are usually suffering with insulin resistance. Being insulin resistant makes it extremely difficult to lose weight. Elevated blood insulin inhibits the action of the body's fat burning enzymes. This means that despite following a healthy diet and exercising, weight loss can be elusive. Berberine improves insulin sensitivity, therefore helps to turn around this metabolic problem. For best results, diabetics can combine it with the eating plan in the book Diabetes Type 2: You Can Reverse It.
A study published in the journal Phytomedicine showed that when obese individuals were given 500 mg of berberine three times each day for 12 weeks, they lost an average of 5 pounds. They also lost an average of 3.6 percent of body fat. In another study conducted on 37 people with insulin resistance, the recruits were given 300mg of berberine three times daily for three months. The study subjects experienced an average drop in Body Mass Index (BMI) from 31.5 to 27.4. That's quite a remarkable shift in only three months.
Herbs that contain berberine have been used in traditional herbal medicine for generations. It is great to see modern research investigating its benefits for today’s health problems.
Please do not discontinue taking any prescription medication without prior discussion with your doctor.
The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.
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I have taken berberine 1200mg once daily and reduced my sugar levels by 50 points . I have heard that berberine reacts with prograf . Can you tell me if it's safe to take?
It’s wonderful to hear how much you’ve reduced your blood sugar. That is very important for maintaining your liver health. We have not experienced problematic interactions between berberine and Prograf in our patients, but each case is unique, so please be monitored closely by your doctor.
Kind regards,
Margaret
Yes berberine should help you significantly and you can take it with metformin. You can find out for sure if you have low insulin or not. Ask your doctor for a C-peptide blood test.
Kind regards,
Margaret
HELP !! WIll BERBERINE interact with Losartan Potassium and Atorvastatin? I take these Rx one each daily..I fear Berberine will cause harm taking Losartan Potassium and Atorvastatin to kidneys and liver.
thanks
There are no known interactions between either of those medications and berberine.
Kind regards,
Margaret
There are no interactions between berberine and levothyroxine, however levothyroxine should be taken on an empty stomach, away from food, medication and supplements. There are no problems in people without a gallbladder.
Kind regards,
Margaret Jasinska
Naturopath for Liverdoctor.com
Has someone conducted a small study of ALT/ AST levels both before/after berberine therapy ? Are the ALT/ AST levels the same or lower (or are they higher) after several weeks on berberine?
Berberine is able to lower elevated liver enzymes. This is a meta-analysis on the topic:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947506/
Kind regards,
Margaret Jasinska
Naturopath for Liverdoctor.com
In our experience we use berberine consistently for long periods of time. Many cases of type 2 diabetes and fatty liver take many months or a few years to resolve. A lot of our patients take berberine to help reduce the risk of type 2 diabetes and liver problems. Berberine protects the liver:https://www.liverdoctor.com/berberine-helps-to-prevent-cirrhosis-of-the-liver/
Kind regards,
Margaret Jasinska
Naturopath for Liverdoctor.com
Yes, it is definitely fine to also be taking berberine.
Kind regards,
Margaret Jasinska
Naturopath for Liverdoctor.com
Thank you for your enquiry/email.
Berberine normalises blood sugar, although most people’s problem is with high blood sugar, which it lowers very effectively.
There are many reasons that low blood sugar can occur and easily get out of whack.
Stress often plays a very large part in fluctuating blood sugar levels, and Dr Cabot prescribes
Magnesium Ultrapotent – ½ teaspoon twice daily in a little water.https://www.liverdoctor.com/magnesium-ultra-potent-powder-210-grams.html
or
Magnesium Complete – 2 tablets twice daily.https://www.liverdoctor.com/magnesium-complete-100-tablets.html.
Coffee often induces the same stress inducing effects, so if you drink coffee, try decaf to see if it makes a difference.
Research also shows that intestinal dysbiosis, especially SIBO, can play havoc with blood sugar stability, and Dr Cabot prescribes
BactoClear – 1 to 2 capsules twice daily. Designed to selectively clear bacterial infections along the digestive and upper respiratory tract. From H.pylori or candida to SIBO and Dysbiotic Large Bowel, Sinusitis and Immune System support.
You may purchase these supplements and Dr Cabot’s books athttps://shop.liverdoctor.com/
Kind regards
Victoria Taylor
Naturopath
Yes, absolutely.
Kind regards,
Margaret Jasinska
Naturopath for Liverdoctor.com
That's great to hear, you sound very motivated.
Please let us know if you have any further questions.
Kind regards,
Jessah Shaw
Nutritionist for Liverdoctor.com
I have fatty Liver and have for many many years not been able to lose weight, have abnormal liver function test results and like the podcast.....have been told to “ just lose weight “ , .....s”stop the carbs”.....” you are at risk of liver cancer”.....and no plan made with the Dr as to how I can do this......I am feeling scared now as I am over 55yrs old and want to be healthy.
The Livatone Plus does not contain Berberine.
However, Berberine and Advanced Curcumin can be purchased separately. Curcumin is the active component of turmeric.
These can be purchased here:https://shop.liverdoctor.com/
Fatty liver can be reversed with a liver friendly diet and supplements that support liver function and repair liver cells.
We recommend you obtain a copy of Dr Cabot’s wonderful book ‘Fatty Liver – You Can Reverse It’ as it provides a complete eating plan with recipes.
Eat less carbohydrate – including sugar, grains and other starchy foods, because the liver converts any excess carbohydrate into fat. Don't drink too much alcohol.
Eliminate all processed foods.
Eat more vegetables, protein and healthy fats.
Drink raw vegetable juices 250 to 300mls 2 to 3 times a week. Dr Cabot’s book ‘Raw Juices can save your life’ has recipes for many different health conditions. Try the ‘Liver Cleanse’ or ‘Liver Tonic’ juices in the book.
To boost liver health and your vitality, Dr Cabot prescribes,
LivaTone Plus - 2 capsules twice a day to help repair damage to the liver and improve the liver’s ability to metabolise fat.
N-Acetyl-Cysteine (NAC 600mg) – 2 capsules twice daily well away from food, if any upset occurs take at the beginning of your meals. This supplement works well with Livatone Plus to get your liver better faster. This supplement hastens liver healing. This supplement is the precursor nutrient of glutathione; the body’s strongest anti-oxidant.
Let us know how you get on.
Kind Regards,
Jessah Robinson
Nutritionist for Liverdoctor.com
We all seemed to be people who are lean and/or athletic, so maybe if you have lower stores of body fat to begin with, the body goes after whatever it can.
Some of the others are right it’s not good to freak out every single time there’s one study that shows contradictory evidence . However we only know the things that have been studied directly-if it’s something people haven’t looked at, there won’t be evidence to support or refute it.
There is plenty that we don’t know about how the body works in general let alone complex chemical compounds and their effect on every body tissue.
So, if you think the berberine might be the problem, stop taking it. See if your pain stops.
This is very doubtful as berberine is a herbal extract that can help lower blood sugar and insulin levels.
We recommend you reduce inflammatory foods such as grains, dairy, sugar, processed food and takeout meals.
We recommend you read this article for further info:https://www.liverdoctor.com/your-muscles-enough-magnesium/
Dr Cabot recommends you take
Magnesium Ultra Potent 1/2 tsp twice daily or Magnesium Complete 2 tabs twice daily as magnesium deficiency is a very common cause of muscle cramps and magnesium works as a muscle relaxant.
Advanced Curcumin 1 cap daily with food to reduce inflammation and help with muscle pain.
These supplements can be purchased here:https://shop.liverdoctor.com/
Let us know how you get on.
Kind Regards,
Jessah Robinson
Nutritional Consultant for Liverdoctor.com